P-263 Epidemiology and characteristics of low or normal AFP vs high AFP in hepatocellular carcinoma – retrospective experience in a tertiary care institute

Hepatocellular Carcinoma is the 6th common cancer in incidence and 2nd Mortality. It a highly fatal tumour, with most cases detected at late stages. Serum AFP best-described used marker HCC. has been recognized for its usefulness prognosis, relationship to various indices of HCC human biology, use non-biopsy diagnosis, assessment responses therapy. But not all tumors are positive or secrete elevated amounts into serum. In this study we investigated epidemiology, Clinical profile, Frequency associated risk factors, Treatment modality compared characteristics Low Normal vs High carcinoma patients reported our Institution Retrospective study. From Jan 2018 Dec 2022, registered, evaluated treated Stanley Medical College, Chennai, Tamilnadu were studied. Total 220 cares registered which Males sex around 87%. Common >40 years age group, mean 57 years. Alcohol cirrhosis present about 56% cases. About 1/3rd viral aetiology. Around 15% have idiopathic cause. 48% multifocal tumours 40% portal vein thrombosis.16% metastasis more lung. Most stage BCLC C 62%, Child Pugh B 68%. started Sorafenib 78%, Resection 12%, TACE 7%. On Comparison AFP, there no much significant difference correlation. Some small high vice versa. Other like MTD (Maximum tumour Diameter), Multifocality, PV thrombus, Cirrhosis, Hemoglobin, Platelets, Bilirubin Alkaline phosphatase also found be significant. All these different MTD. Those advanced stage. So early screening candidates factors may help diagnosis. For even large low normal AFP. need do other markers PIVKA, DCP (Des-gamma-carboxy prothrombin), EpCAM, Glpican-3 & Hepatic miRs. explore detail so as apply HCCs.